Download Animal Models of Movement Disorders by Mark LeDoux (Editor) PDF

By Mark LeDoux (Editor)

Using animal types is a key element of clinical examine in several fields of drugs. This e-book vigorously examines the $64000 contributions and alertness of animal types to the knowledge of human circulate issues and may function an important source for easy neuroscientists engaged in flow issues study. educational clinicians, translational researchers and uncomplicated scientists are introduced jointly to attach experimental findings made in several animal types to the scientific positive aspects, pathophysiology and remedy of human flow issues. an essential function of this e-book is an accompanying DVD with videos of human move issues and their corresponding animal versions. The booklet is split into sections on Parkinson illness, Huntington illness, dystonia, tremor, paroxysmal circulate problems, ataxia, myoclonus, stressed legs syndrome, drug-induced circulation issues, a number of procedure atrophy, revolutionary supranuclear palsy/corticobasal degeneration and spasticity. This booklet serves as an important source for either clinicians drawn to the technological know-how being generated with animal types and easy scientists learning the pathogenesis of specific circulate problems. * offers a unmarried finished source on animal types of circulate issues that educational clinicians, translational researchers, and simple neuroscientists can consult with* contains contributions by means of professional move ailment clinicians and top-level researchers within the box* incorporates a DVD containing over a hundred and seventy videos of human circulation issues and the corresponding animal types

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Cozens, A. Harper, C. Hetherington, M. Lawton, et al. 1996. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87:493–506. , H. Walker, H. Z. Zhu, T. Fielder, J. M. Thompson. 2000.

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2000 mouse wild-type human asynuclein transgenic murine platelet-derived growth factor promoter nuclear & cytoplasmic inclusions in cortex, hippocampus & SNpc, rotarod deficits at 1 yr Masliah et al. 2000 mouse wild-type & A53T human a-synuclein transgenic murine Thy-1 promoter transgene not expressed in SNpc, prominent degeneration of brainstem & spinal cord motoneurons, motor abnormalities by 3 wks of age van der Putten et al. 2000 mouse A53T a-synuclein transgenic human A53T a-synuclein variant under direction of the mouse prion protein promoter adult mice (>8 mo) develop progressive paresis & intracytoplasmic inclusions Giasson et al.

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