Download Advances in DNA Damage and Repair: Oxygen Radical Effects, by Steven Akman, Regen Drouin, Gerald Holmquist (auth.), Miral PDF

By Steven Akman, Regen Drouin, Gerald Holmquist (auth.), Miral Dizdaroglu, Ali Esat Karakaya (eds.)

Damage to DNA by means of either exogenous and endogenous resources is more and more considered as hugely vital within the initiation and development of melanoma and within the occurance of alternative pathological occasions. DNA harm brought on by reactive oxygen-derived species, also referred to as oxidative DNA harm, is so much the widespread kind encountered through cardio cells. Mechanistic stories of carcinogenesis point out an incredible function of this sort of harm to DNA. there's additionally powerful proof to aid the function of oxidative DNA harm within the getting older method. DNA harm is adverse in vivo through fix structures. If now not repaired, DNA harm could lead on to harmful organic effects. for this reason, the fix of DNA harm is considered one of many crucial occasions in all lifestyles types. in recent times the sphere of DNA fix has flourished as a result of new findings on DNA fix mechanisms and the molecular foundation of melanoma. an in depth wisdom of mechanisms of DNA harm and service, and the way person fix enzymes functionality could lead to manipulation of DNA fix in cells and eventually to a rise of the resistence of human cells to DNA-damaging brokers. This quantity covers the latest devlopments during this examine box and comprises contributions from scientists operating within the fields of biochemistry, molecular biology, enzymology, biomedical technology, and radiation biology.

Show description

Read or Download Advances in DNA Damage and Repair: Oxygen Radical Effects, Cellular Protection, and Biological Consequences PDF

Similar nonfiction_9 books

Dioxins and Health, Second Edition

Dioxins are the main powerful, popular, and durable of the continual natural pollution (POPS), and are of significant curiosity in public health and wellbeing, toxicology, chemistry, medication, legislations, and to regulatory corporations around the globe. within the years when you consider that e-book of the 1st variation of Dioxins and healthiness, significant advances were made in human epidemiology in addition to in animal reports.

Phytoremediation of Metal-Contaminated Soils

Phytoremediation, using crops to remediate environmental media, is being pursued as a brand new method for the cleanup of infected soils and waters, together with groundwater. Plant-assisted bioremediation, occasionally often called one of those phytoremediation, comprises the interplay of plant roots and the microorganisms linked to those root platforms to re- diate soils containing increased concentrations of natural compounds.

Radionuclide and Hybrid Bone Imaging

This e-book, written through authors with nationwide and overseas reputations within the box, covers all elements of radionuclide and hybrid bone imaging. Introductory sections current the elemental technological know-how and look at the present prestige and barriers of traditional radiological thoughts. The underlying ideas of PET-CT and SPECT-CT are conscientiously defined, and the worth of alternative puppy and SPECT tracers, assessed.

Caper: The Genus Capparis

Caper: The Genus Capparis offers a pharmacognostic and ethnopharmacological exploration of the genus Capparis, emphasizing its medicinal capability. there's a lengthy heritage of secure utilization of Capparis components either in nutrition and as plant medications during the global, and the main points of this utilization are summarized in 39 tables protecting various Capparis species.

Additional resources for Advances in DNA Damage and Repair: Oxygen Radical Effects, Cellular Protection, and Biological Consequences

Sample text

In the Fenton mechanism, oxidative stress could cause release of catalytic copper or iron within cells which could then bind to DNA. Metal ions are naturally occurring metal constituents of the cell nucleus (Pezzano 1980, Bryan et al 1981). Generation of OR' by reaction of H 20 2 with the transition metal ions already bound onto the DNA would lead to strand breakage, base modification and deoxysugar fragmentation. In the nuclease activation mechanism, oxidative stress leads to the inactivation of Ca 2+-binding 22 O.

Pratt (1993). Ind. Health 9: 63-75. B. G. M. G. So (1980). Degradation of deoxyribonucleic acid by a I, I O-phenanthrolinecopper complex: the role of hydroxyl radicals, Biochemistry 19: 5987-5991. K. A. E. R. S. Sigman (1981). Cleavage of DNA by the phenanthroline-copper ion complex. Superoxide mediates the reaction dependent on NADH and hydrogen peroxide, J. Am. Chem. Soc. 103: 3582-3584. D. M. Schaefer, Q. Liu, C. -C. Yin (1995). Supranutritional administration of vitamins E and C improves oxidative stability of beef, J.

It is possible that under certain conditions the BLM-Fe(III)-02 - might decompose to yield 02'-' and BLMFe(III)-02H- to release OR (Sugiura et al. 1982, Petering et al 1990). Hydroxyl radical is not necessarily the major DNA damaging species in the bleomycin system. The bleomycin-iron(III) complex by itself is inactive in inducing damage in DNA. Oxygen and a reducing agent or hydrogen peroxide are required for the damage to DNA to occur. DNA cleavage by bleomycin releases some free bases and base propenals in amounts that are stoichiometric with strand cleavage (Burger et al 1981, Giloni et al 1981).

Download PDF sample

Rated 4.46 of 5 – based on 12 votes